Julie Donaldson on ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1.
COMMENT This study by Sannerud et al. expands our understanding of how BACE1 meets up with APP in endocytic compartments to generate amyloid-β peptides. Although much is known about clathrin-dependent forms of endocytosis and the trafficking itinerary of plasma m